Posttraumatic stress disorder (PTSD) and alcohol and other drug (AOD) use disorders are frequently co-occurring disorders. Individually, they each pose significant public health problems, which are substantially exacerbated by their comorbidity. The PTSD/AOD Virtual Clinical Trials (VCT) study is a National Institute on Alcohol Abuse and Alcoholism funded integrative data analysis project that will synthesize disparate data from 50 existing PTSD and AOD treatment studies. Led by a team of experts in PTSD/AOD treatment and clinical trials from Rutgers Center of Alcohol Studies (Hien (MPI) & Ruglass), Research Triangle Institute (Morgan-Lopez (MPI) & Saavedra), Medical University of South Carolina (Back, Brady & Killeen) & Columbia University (Campbell), the VCT study will use novel data analytic approaches to provide clear and definitive recommendations regarding which, how and for whom PTSD/AOD treatments are optimally effective. The PTSD-AOD VCT Study executive team members are hosting a kick-off party at the International Society for Traumatic Stress Studies (ISTSS) convention in Washington, D.C.